The Role:
We are seeking an experienced Director, Global Site Engagement & Patient Recruitment, Respiratory Programs to lead site engagement and enrollment strategy across Generate’s late-phase global respiratory portfolio, including asthma and COPD studies. This is a people leader role responsible for building and executing a high-impact global model for investigator identification, investigator engagement, site performance, and patient recruitment across Phase II–IV clinical programs.
This leader will manage and develop a team of Clinical Trial Liaisons (CTLs) and will partner closely with Clinical Operations, Clinical Development, Biometrics, and external CRO and vendor partners to identify investigators, accelerate enrollment, improve the site experience, and support high-quality trial execution. The Director will operate as both a strategic leader and a hands-on problem solver—using data, real-world insights, and strong site partnerships to identify high-performing sites and networks, remove enrollment barriers, and continuously strengthen study delivery across regions.
Here's how you will contribute:
- Own and drive global site engagement and patient recruitment strategy across late-phase respiratory clinical programs, including Phase II, Phase III, and Phase IV studies in asthma and COPD.
- Lead the development and execution of study- and program-level investigator identification, enrollment strategies that improve site readiness, recruitment performance, retention, and overall trial execution.
- Manage, coach, and develop a team of CTLs, setting clear expectations, building capabilities, and creating a high-performance, collaborative, and accountable team culture.
- Partner with Clinical Operations, Clinical Development, Biometrics, CRO and vendor partners to remove operational barriers, improve the site experience, and deliver studies on time.
- Serve as a senior escalation point for site engagement and enrollment challenges, working directly with internal teams, CROs, investigators, and study sites to resolve issues quickly and effectively.
- Use study performance data, site intelligence, and real-world insights to identify high-performing sites and networks and continuously refine site selection, activation, and enrollment strategies.
- Shape global and regional site engagement plans that reflect country- and region-specific considerations, patient pathways, standards of care, operational realities, and representativeness goals.
- Build and sustain strong relationships with investigators, site staff, site networks, and key external partners to strengthen Generate’s reputation as a thoughtful, responsive, and high-value sponsor.
- Guide CTLs and study teams in the delivery of protocol and study-specific training to site personnel, ensuring consistent communication, protocol understanding, and operational readiness.
- Oversee site-facing recruitment and retention approaches, ensuring messaging, materials, and support plans are practical, compliant, and tailored to the realities of respiratory trial execution.
- Translate site feedback into actionable recommendations for protocol execution, recruitment planning, visit burden, and operational improvements.
- Contribute strategically to protocol and study planning by bringing forward site, investigator, and patient insights that improve feasibility and reduce barriers to participation.
- Monitor enrollment and site performance trends across the respiratory portfolio, proactively identifying risks, intervention opportunities, and lessons learned to inform future studies.
- Maintain a working knowledge of global regulatory and GCP expectations related to trial conduct, site engagement, and enrollment execution.
Leadership Responsibilities
- Set a high bar for performance, accountability, and collaboration across the CTL team, with clear goals, timely feedback, and strong follow-through.
- Build and develop a high-performing, diverse, and collaborative team by coaching individuals, sharing knowledge, and creating opportunities for growth.
- Ensure the CTL team understands how its work supports broader clinical and company priorities, connecting day-to-day execution with long-term program goals.
- Foster a culture of transparent, courageous, and thoughtful communication across the team and in cross-functional settings.
- Encourage adaptability, resilience, and calculated risk-taking, helping the team respond effectively to changing enrollment dynamics, operational challenges, and emerging data.
- Lead with a hands-on, low-ego style that balances strategic thinking with operational execution and a willingness to step in where needed.
The Ideal Candidate will have:
- Bachelor’s degree in a scientific, healthcare, or related field required.Advanced degree preferred, but not required.
- 12+ years of clinical research experience in biotech, pharmaceutical, or CRO environments, including substantial experience in investigator identification, site engagement, patient recruitment, and late-phase global study execution.
- Demonstrated success leading site engagement and enrollment strategy for complex, multi-site, global clinical trials, ideally in respiratory programs.
- Deep understanding of site dynamics, investigator and coordinator needs, and the operational factors that drive site activation, enrollment, retention, and sustained performance.
- Prior people management experience, including direct management and development of field-based or site-facing clinical teams.
- Strong knowledge of global clinical operations, ICH-GCP, and regional regulatory considerations relevant to study conduct and patient recruitment.
- Experience identifying high-performing sites and site networks and using data, feasibility inputs, and study performance signals to refine recruitment and site strategy over time.
- Strong cross-functional leadership skills with the ability to influence without authority, align stakeholders, and drive execution in a matrixed environment.
- Data-driven mindset with the ability to interpret study metrics, spot patterns, and translate insights into practical action plans.
- Comfortable operating in a fast-paced biotech environment with ambiguity, evolving priorities, and the need to work at both strategic and execution levels.
- Excellent communication, relationship-building, and problem-solving skills.
- Willingness and ability to travel regionally and globally as needed.
Nice to Have (Optional)
- Direct experience in asthma, COPD, or broader respiratory clinical development.
- Experience with enrollment acceleration, rescue planning, or recovery strategies in underperforming studies.
- Prior experience as a CRA, CTL, or in another site-facing role.
- Experience working with community-based sites, academic centers, and site networks across multiple geographies.
Who Will Love This Job:
At Generate, you will help shape how global respiratory trials are delivered in a company built to rethink what is possible in drug development. You will work at the intersection of science, technology, and execution—leading a critical function that strengthens site partnerships, expands patient access to trials, and helps bring innovative therapies to patients faster. This is an opportunity to build team capability, influence portfolio-level strategy, and make a visible impact in a fast-moving, mission-driven environment.
About Generate Biomedicines
We are a clinical-stage generative biology company pioneering the AI revolution in drug design and development. We are advancing a new approach to drug creation—one grounded in the ability to design proteins with defined biological intent. By integrating machine learning with large-scale experimentation, this approach aims to reduce the uncertainty, time, and cost associated with developing protein-based medicines.
Founded in 2018, we are advancing a growing pipeline of clinical and preclinical programs across multiple disease areas and protein modalities. By unifying computational design and clinical development within a single operating model, we translate this approach into clinical-stage programs and are leading a shift from traditional drug discovery toward systematic drug generation.
At Generate:Biomedicines, we collaborate across disciplines in new ways to invent and innovate. We bring diverse perspectives to a shared goal of delivering better medicines to patients in need, faster, guided by our values and leadership behaviors.
Generate:Biomedicines is committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.
Recruitment & Staffing Agencies: Generate:Biomedicines does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Generate:Biomedicines or its employees is strictly prohibited unless contacted directly by the Company’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Generate:Biomedicines and the Company will not owe any referral or other fees with respect thereto.
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